Xanomeline, CAS 141064-23-5

Xanomeline, CAS 141064-23-5, Stock 420g, Assay 99.6%, White powder, Water 0.25%, Single Impurity 0.4%.

Xanomeline

Xanomeline s a muscarinic acetylcholine receptor agonist with reasonable selectivity for the M1 and M4 subtypes, though it is also known to act as a M5 receptor antagonist. It has been studied for the treatment of both Alzheimer's disease and schizophrenia, particularly the cognitive and negative symptoms, although gastrointestinal side effects led to a high drop-out rate in clinical trials. Despite this, xanomeline has been shown to have reasonable efficacy for the treatment of schizophrenia symptoms, and one recent human study found robust improvements in verbal learning and short-term memory associated with xanomeline treatment.

Product Details:

Name: Xanomeline oxalate

CAS#: 141064-23-5 (oxalate)

Chemical Formula: C16H25N3O5S

Exact Mass: 281.1562

Molecular Weight: 371.452

Elemental Analysis: C, 51.74; H, 6.78; N, 11.31; O, 21.54; S, 8.63

Specification:

Synonym: LY-246708; LY246708; LY 246708; Xanomeline; Memcor; NNC-110232; Hexyloxy-TZTP; HexyloxyTZTP. Xanomeline oxalate

IUPAC/Chemical Name: 3-(hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole oxalate

InChi Key: ZJOUESNWCLASJP-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H23N3OS.C2H2O4/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;3-1(4)2(5)6/h8H,3-7,9-11H2,1-2H3;(H,3,4)(H,5,6)

SMILES Code: CN1CCC=C(C2=NSN=C2OCCCCCC)C1

Appearance: White to off-white solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: