Zandelisib, CAS 1401436-95-0

Zandelisib, CAS 1401436-95-0, Stock 387g, Assay 99.6%, White powder, Water 0.25%, Single Impurity 0.4%.

Zandelisib

Zandelisib, also known as PWT143 and ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, PI3K-delta inhibitor PWT143 selectively inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.

Product Details:

Name: Zandelisib

CAS#: 1401436-95-0

Chemical Formula: C31H38F2N8O

Exact Mass: 576.3137

Molecular Weight: 576.6968

Elemental Analysis: C, 64.56; H, 6.64; F, 6.59; N, 19.43; O, 2.774

Specification:

Synonym: Zandelisib

IUPAC/Chemical Name: 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-methyl-1- [2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl}-6-(morpholin- 4-yl)-1,3,5-triazin-2-amine

InChi Key: WPFUFWIHMYZXSF-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H38F2N8O/c1-31(2,20-22-8-4-5-9-23(22)21-12-14-39(3)15-13-21)38-28-35-29(40-16-18-42-19-17-40)37-30(36-28)41-25-11-7-6-10-24(25)34-27(41)26(32)33/h4-11,21,26H,12-20H2,1-3H3,(H,35,36,37,38)

SMILES Code: CC(NC1=NC(N2C3=CC=CC=C3N=C2C(F)F)=NC(N4CCOCC4)=N1)(C)CC5=CC=CC=C5C6CCN(C)CC6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

HS Tariff Code: 2934.99.9001

Certification: