CO-1686(Rociletinib), CAS 1374640-70-6

  • CO-1686(Rociletinib), CAS 1374640-70-6

CO-1686(Rociletinib), CAS 1374640-70-6
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1374640-70-6
  • Stock: 1.25kg
  • Assay: 98.47%

CO-1686(Rociletinib), CAS 1374640-70-

CO-1686(Rociletinib), CAS 1374640-70-6Stock 1249g, Assay 98.47%, White powderWater 0.32%, Single Impurity 0.67%.


Rociletinib, also known as AVL-301 and CO1686, is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. EGFR inhibitor CO-1686 binds to and inhibits mutant forms of EGFR, including T790M, thereby leading to cell death of resistant tumor cells. Compared to other EGFR inhibitors, CO-1686 inhibits T790M, a secondary acquired resistance mutation, as well as other mutant EGFRs and may have therapeutic benefits in tumors with T790M-mediated resistance to other EGFR tyrosine kinase inhibitors.

Product Details:

Name: Rociletinib

CAS#: 1374640-70-6 (free base)

Chemical Formula: C27H28F3N7O3

Exact Mass: 555.22057

Molecular Weight: 555.55

Elemental Analysis: C, 58.37; H, 5.08; F, 10.26; N, 17.65; O, 8.64


Synonym: CO1686; CO-1686; CO 1686; AVL301; AVL 301; AVL-301; CNX419; CNX 419; CNX-419; Rociletinib.

IUPAC/Chemical Name: N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide


InChi Code: InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)


Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001