Zavegepant, CAS 1337918-83-8

Zavegepant, CAS 1337918-83-8, Stock 350g, Assay 99.8%, White powder, Water 0.23%, Single Impurity 0.2%.

Zavegepant

Zavegepant, also known as Vazegepant, BHV-3500 and BMS 742413, is a highly potent, selective and structurally unique small molecule CGRP receptor antagonist. Vazegepant is the first and only CGRP receptor antagonist for intranasal administration currently in development for the acute treatment of migraine.

Product Details:

Name: Zavegepant

CAS#: 1337918-83-8 (free base)

Chemical Formula: C36H46N8O3

Exact Mass: 638.3693

Molecular Weight: 638.817

Elemental Analysis: C, 67.69; H, 7.26; N, 17.54; O, 7.51

Specification:

Synonym: Zavegepant, Vazegepant; BMS 742413; BMS-742413; BMS742413; BHV-3500; BHV 3500; BHV3500;

IUPAC/Chemical Name: (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide

InChi Key: JJVAPHYEOZSKJZ-JGCGQSQUSA-N

InChi Code: InChI=1S/C36H46N8O3/c1-24-19-25(20-28-23-37-40-33(24)28)21-32(35(46)43-17-15-42(16-18-43)29-9-11-41(2)12-10-29)39-36(47)44-13-7-26(8-14-44)30-22-27-5-3-4-6-31(27)38-34(30)45/h3-6,19-20,22-23,26,29,32H,7-18,21H2,1-2H3,(H,37,40)(H,38,45)(H,39,47)/t32-/m1/s1

SMILES Code: CN1CCC(N2CCN(C([C@H](NC(N3CCC(C4=CC(C=CC=C5)=C5NC4=O)CC3)=O)CC6=CC(C=NN7)=C7C(C)=C6)=O)CC2)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: