Netarsudil HCl, CAS 1253952-02-1

  • Netarsudil HCl, CAS 1253952-02-1

Netarsudil HCl, CAS 1253952-02-1
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1253952-02-1
  • Stock: 744g
  • Assay: 98.35%

Netarsudil HCl, CAS 1253952-02-1

Netarsudil HCl, CAS 1253952-02-1, Stock 744g, Assay 98.35%, White powder, Water 0.36%, Single Impurity 0.37%.


Netarsudil HCl

Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and​/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.


Product Details:

Name: Netarsudil HCl

CAS#: 1253952-02-1 (HCl)

Chemical Formula: C28H29Cl2N3O3

Exact Mass: 525.1586

Molecular Weight: 526.45

Elemental Analysis: C, 63.88; H, 5.55; Cl, 13.47; N, 7.98; O, 9.12


Specification:

Synonym: Netarsudil; Netarsudil hydrochloride; AR-13324 HCl; AR-13324 HCl; AR13324 HCl; AR13324 HCl; Rhopressa;

IUPAC/Chemical Name: [4-[(2S)-3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate dihydrochloride

InChi Key: LDKTYVXXYUJVJM-FBHGDYMESA-N

InChi Code: InChI=1S/C28H27N3O3.2ClH/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24;;/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32);2*1H/t26-;;/m1../s1

SMILES Code: O=C(OCC1=CC=C([C@@H](CN)C(NC2=CC3=C(C=NC=C3)C=C2)=O)C=C1)C4=CC=C(C)C=C4C.[H]Cl.[H]Cl

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: