Abemaciclib, CAS 1231929-97-7

  • Abemaciclib, CAS 1231929-97-7

Abemaciclib, CAS 1231929-97-7
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1231929-97-7
  • Stock: 1.03kg
  • Assay: 98.36%

Abemaciclib, CAS 1231929-97-7

Abemaciclib, CAS 1231929-97-7Stock 1028g, Assay 98.36%, White powderWater 0.27%, Single Impurity 0.19%.


Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

Product Details:

Name: Abemaciclib free base

CAS#: 1231929-97-7 (free base)

Chemical Formula: C27H32F2N8

Exact Mass: 506.2718

Molecular Weight: 506.59

Elemental Analysis: C, 64.01; H, 6.37; F, 7.50; N, 22.12


Synonym: LY2835219; LY2835219; LY 2835219; Abemaciclib.

IUPAC/Chemical Name: N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine


InChi Code: InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)


Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0-4 C for short term (weeks), and -20 C for long term (months)

HS Tariff Code: 2934.99.9001