CAS 113225-07-3 | ALVO-009 : Alvocidib Hydrochloride
(World's Largest Pharmaceutical Supplier)

Introduction

CAS 113225-07-3 is a chemical compound with a molecular formula of C20H19N3O4. It is commonly referred to as Candesartan cilexetil. This compound is widely used in the pharmaceutical industry to treat hypertension and heart failure.

Chemical Properties

CAS 113225-07-3 has a molecular weight of 416.39 g/mol. It is a white to off-white crystalline powder that is soluble in methanol and ethanol. This compound has a melting point of 106-110°C and a pKa value of 4.8.

Synthesis

The synthesis of Candesartan cilexetil involves the reaction of Candesartan with ethyl chloroformate in the presence of a base. The resulting compound is then treated with ethanol to yield the final product.

Pharmacological Properties

Candesartan cilexetil is an angiotensin II receptor blocker (ARB). It works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow. This results in a decrease in blood pressure and an increase in blood flow. This compound is also known to have antioxidant and anti-inflammatory properties.

Applications

CAS 113225-07-3 is primarily used in the pharmaceutical industry to treat hypertension and heart failure. It is available in tablet form and is often used in combination with other drugs to achieve optimal results. This compound is also being investigated for its potential use in the treatment of other conditions such as diabetic nephropathy and migraine.

Safety

Candesartan cilexetil is generally considered safe when used as directed. However, like all medications, it may cause side effects such as dizziness, headache, and fatigue. In rare cases, it may also cause serious side effects such as liver damage and allergic reactions.

Conclusion

CAS 113225-07-3, also known as Candesartan cilexetil, is a widely used medication in the treatment of hypertension and heart failure. Its ability to block the action of angiotensin II makes it an effective treatment option for these conditions. Ongoing research is also exploring its potential use in the treatment of other conditions.