AZ3146, CAS 1124329-14-1
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AZ3146, CAS 1124329-14-1

AZ3146, CAS 1124329-14-1, Stock 1057g, Assay 98.56%, White powder, Water 0.2%, Single Impurity 0.19%.

AZ3146

AZ3146 is a novel and potent Mps1 inhibitor, which was used to probe the role of Mps1's catalytic activity during mitosis. AZ3146 also inhibits FAK, JNK1, JNK2, KSP and Kit. In in vitro kinase assays, AZ3146 inhibited human Mps1Cat with an IC50 (50% inhibitory concentration) of ~35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells.

Product Details:

Name: AZ3146

CAS#: 1124329-14-1

Chemical Formula: C24H32N6O3

Exact Mass: 452.25359

Molecular Weight: 452.55

Elemental Analysis: C, 63.70; H, 7.13; N, 18.57; O, 10.61

Specification:

Synonym: AZ3146; AZ 3146; AZ-3146

IUPAC/Chemical Name: 9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one

InChi Key: YUKWVHPTFRQHMF-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)

SMILES Code: O=C1N(C)C2=CN=C(NC3=CC=C(OC4CCN(C)CC4)C=C3OC)N=C2N1C5CCCC5

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: