Entrectinib(RXDX-101), CAS 1108743-60-7

  • Entrectinib(RXDX-101), CAS 1108743-60-7

Entrectinib(RXDX-101), CAS 1108743-60-7
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1108743-60-7
  • Stock: 925g
  • Assay: 98.66%

Entrectinib(RXDX-101), CAS 1108743-60-7

Entrectinib(RXDX-101), CAS 1108743-60-7Stock 925g, Assay 98.66%, White powderWater 0.24%, Single Impurity 0.32%.


Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. RXDX-101 has demonstrated potent pharmacological activity in preclinical studies and has the potential to be first-in-class against the Trk family of kinases. PXDX-101 has been well tolerated in patients with advanced solid tumors. PXDX-101 is currently in clinical trials, and is being developed by Ignyta.

Product Details:

Name: Entrectinib

CAS#: 1108743-60-7

Chemical Formula: C31H34F2N6O2

Exact Mass: 560.27113

Molecular Weight: 560.64

Elemental Analysis: C, 66.41; H, 6.11; F, 6.78; N, 14.99; O, 5.71


Synonym: RXDX101; RXDX 101; RXDX-101; NMS E628; NMSE628; NMS-E628; Entrectinib

IUPAC/Chemical Name: N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide


InChi Code: InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)


Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001