CAS 1092364-38-9: Poziotinib (HM-781-36)

  • CAS 1092364-38-9: Poziotinib (HM-781-36)

CAS 1092364-38-9: Poziotinib (HM-781-36)
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  • CAS Number: 1092364-38-9
  • Stock: 320g
  • Assay: 99.50%

Poziotinib (HM-781-36) , CAS 1092364-38-9

Poziotinib, CAS 1092364-38-9, Stock 320g, Assay 99.5%, White powder, Water 0.16%, Single Impurity 0.5%.


Poziotinib

Poziotinib , also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival.


Product Details:

Name: Poziotinib

CAS#: 1092364-38-9 (free base)

Chemical Formula: C23H21Cl2FN4O3

Exact Mass: 490.09747

Molecular Weight: 491.34

Elemental Analysis: C, 56.22; H, 4.31; Cl, 14.43; F, 3.87; N, 11.40; O, 9.77


Specification:

Synonym: HM781-36B; HM78136B; HM-78136B; HM 78136B; NOV120101; NOV-120101; NOV 120101; Poziotinib

IUPAC/Chemical Name: 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one

InChi Key: LPFWVDIFUFFKJU-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)

SMILES Code: C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O

Appearance: Pale yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

HS Tariff Code: 2934.99.9001

Certification: