CAS 1039948-89-4 | APAB-003 : Apabetalone
(World's Largest Pharmaceutical Supplier)

Introduction:

CAS 1039948-89-4 is a chemical compound with a molecular formula of C24H29ClN2O2. It is also known by its trade name, Ixazomib, and is a proteasome inhibitor used in the treatment of multiple myeloma.

Chemical Properties:

CAS 1039948-89-4 is a white to off-white powder that is soluble in dimethyl sulfoxide (DMSO) and slightly soluble in water. It has a molecular weight of 452.96 g/mol and a melting point range of 247-251°C.

Applications:

Ixazomib is used in the treatment of multiple myeloma, a type of cancer that affects plasma cells in the bone marrow. It works by inhibiting the proteasome, which is responsible for breaking down proteins in the cell. By inhibiting the proteasome, Ixazomib prevents the cancer cells from breaking down and allows them to accumulate, leading to cell death.

Ixazomib is usually given in combination with other drugs, such as lenalidomide and dexamethasone, as a first-line treatment for multiple myeloma. It can also be used as a maintenance therapy to prevent the cancer from returning after initial treatment.

Side Effects:

Like all drugs, Ixazomib can cause side effects. The most common side effects include diarrhea, nausea, vomiting, constipation, rash, fatigue, and peripheral neuropathy. More serious side effects include liver toxicity, thrombocytopenia, and peripheral edema.

Conclusion:

CAS 1039948-89-4, also known as Ixazomib, is a proteasome inhibitor used in the treatment of multiple myeloma. It is a white to off-white powder that is soluble in DMSO and slightly soluble in water. Ixazomib is usually given in combination with other drugs and can cause side effects such as diarrhea, nausea, and liver toxicity. Despite its side effects, Ixazomib has shown promise in the treatment of multiple myeloma and is an important drug in the fight against cancer.