Ceritinib (Ldk378), CAS 1032900-25-6

  • Ceritinib (Ldk378), CAS 1032900-25-6

Ceritinib (Ldk378), CAS 1032900-25-6
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1032900-25-6
  • Stock: 905g
  • Assay: 98.73%

Ceritinib (Ldk378), CAS 1032900-25-6

Ceritinib (Ldk378), CAS 1032900-25-6Stock 905g, Assay 98.73%, White powderWater 0.44%, Single Impurity 0.33%.


LDK378

Ceritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib. LDK378 blocks the ALK protein and stops it sending growth signals to cancer cells, which may stop them growing. Ceritinib was approved in April 2014.


Product Details:

Name: Ceritinib free base

CAS#: 1032900-25-6 (free base)

Chemical Formula: C28H36ClN5O3S

Exact Mass: 557.22274

Molecular Weight: 558.14

Elemental Analysis: C, 60.25; H, 6.50; Cl, 6.35; N, 12.55; O, 8.60; S, 5.75


Specification:

Related CAS #: 1032900-25-6 (free base)   1380575-43-8 (2HCl)   1190399-48-4 (xHCl)    

Synonym: LDK-378; LDK378; LDK 378; Ceritinib, brand name: Zykadia.

IUPAC/Chemical Name: 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

InChi Key: VERWOWGGCGHDQE-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)

SMILES Code: ClC1=CN=C(NC2=CC(C)=C(C3CCNCC3)C=C2OC(C)C)N=C1NC4=CC=CC=C4S(C(C)C)(=O)=O

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: