Copanlisib(BAY80-6946), CAS 1032568-63-0

  • Copanlisib(BAY80-6946), CAS 1032568-63-0

Copanlisib(BAY80-6946), CAS 1032568-63-0
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1032568-63-0
  • Stock: 1.53kg
  • Assay: 98.64%

Copanlisib(BAY80-6946), CAS 1032568-63-0

Copanlisib(BAY80-6946), CAS 1032568-63-0, Stock 1532g, Assay 98.64%, White powder, Water 0.35%, Single Impurity 0.34%.


Copanlisib(BAY80-6946)

Copanlisib also known as BAY 80-6946, is a potent phosphoinositide 3-kinase (PI3K) inhibitor. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Copanlisib was approved for the treatment of adult patients experiencing relapsed follicular lymphoma who have received at least two prior systemic therapies.


Product Details:

Name: Copanlisib free base

CAS#: 1032568-63-0 (free base)

Chemical Formula: C23H28N8O4

Exact Mass: 480.22335

Molecular Weight: 480.52

Elemental Analysis: C, 57.49; H, 5.87; N, 23.32; O, 13.32


Specification:

Synonym: BAY 80-6946; BAY80-6946; BAY-80-6946; BAY806946; BAY-806946; BAY 806946; Copanlisib free base

IUPAC/Chemical Name: 2-amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide

InChi Key: PZBCKZWLPGJMAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32)

SMILES Code: O=C(C1=CN=C(N)N=C1)NC2=NC3=C(C=CC(OCCCN4CCOCC4)=C3OC)C5=NCCN25.

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: BAY80-6946 does not have good solubility in common solvents. BAY80-6946 is soluble in 5% HCl, slightly soluble in DMSO, not soluble in water.

Shelf Life: >2 years if stored properly

Drug Formulation: Method 1: For in vitro studies, 5 mmol/L stock solution of BAY 80-6946 (in dimethyl sulfoxide with 10 mmol/L trifluoroacetic acid) was used - see Mol Cancer Ther. 2013 Nov;12(11):2319-30.

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: