CAS 1025504-45-3: Valbenazine free base
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Valbenazine free base, CAS 1025504-45-3

Valbenazine free base,  CAS 1025504-45-3, Stock 128g, Assay 99.7%, White powder, Water 0.13%, Single Impurity 0.3%.

Valbenazine free base

Valbenazine, also known as NBI-98854 and MT-5199, is a potent and selective VMAT2 inhibitor. NBI-98854 is effective in regulating the levels of dopamine release during nerve communication, while at the same time having minimal impact on the other monoamines. NBI-98854 is promising agent for the treatment of tardive dyskinesia.NBI-98854 significantly improved tardive dyskinesia and was well tolerated in patients. These results support the phase 3 clinical trials of NBI-98854 now underway.

Product Details:

Name: Valbenazine free base

CAS#: 1025504-45-3 (free base)

Chemical Formula: C24H38N2O4

Exact Mass: 418.2832

Molecular Weight: 418.578

Elemental Analysis: C, 68.87; H, 9.15; N, 6.69; O, 15.29

Specification:

Synonym: NBI-98854; NBI 98854; NBI98854; MT-5199; MT 5199; MT5199; Valbenazine; Ingrezza;

IUPAC/Chemical Name: (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate

InChi Key: GEJDGVNQKABXKG-CFKGEZKQSA-N

InChi Code: InChI=1S/C24H38N2O4/c1-14(2)9-17-13-26-8-7-16-10-21(28-5)22(29-6)11-18(16)19(26)12-20(17)30-24(27)23(25)15(3)4/h10-11,14-15,17,19-20,23H,7-9,12-13,25H2,1-6H3/t17-,19-,20-,23+/m1/s1

SMILES Code: N[C@@H](C(C)C)C(O[C@H]1[C@H](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[C@@]2([H])C1)=O

Appearance: White to off-white crystalline powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: