PF-03882845, CAS 1023650-66-9

PF-03882845, CAS 1023650-66-9, Stock 420g, Assay 99.5%, White powder, Water 0.19%, Single Impurity 0.5%.

PF-03882845

PF-03882845 is a highly potent (IC50=6.3‐13.4nM,10% fetal bovine serum & IC50= 0.504–1.11 nM, absence of serum) selective orally bioavailable mineralocorticoid receptor antagonist. It prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy.

Product Details:

Name: PF-03882845

CAS#: 1023650-66-9

Chemical Formula: C24H22ClN3O2

Exact Mass: 419.1401

Molecular Weight: 419.909

Elemental Analysis: C, 68.65; H, 5.28; Cl, 8.44; N, 10.01; O, 7.62

Specification:

Synonym: PF-03882845; PF 03882845; PF03882845.

IUPAC/Chemical Name: (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid

InChi Key: XNULRSOGWPFPBL-REWPJTCUSA-N

InChi Code: InChI=1S/C24H22ClN3O2/c25-21-12-18(8-5-17(21)13-26)28-23(14-3-1-2-4-14)20-10-6-15-11-16(24(29)30)7-9-19(15)22(20)27-28/h5,7-9,11-12,14,20,23H,1-4,6,10H2,(H,29,30)/t20-,23-/m0/s1

SMILES Code: O=C(C1=CC=C2C(CC[C@]3([H])[C@H](C4CCCC4)N(C5=CC=C(C#N)C(Cl)=C5)N=C23)=C1)O

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: