CAS 101827-46-7: Butenafine HCl
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- CAS Number: 101827-46-7
- Stock: 298g
- Assay: 99.50%
Butenafine HCl, CAS 101827-46-7:
Butenafine HCl, CAS 101827-46-7, Stock 298g, Assay 99.5%, White powder, Water 0.21%, Single Impurity 0.5%.
Butenafine HCl, CAS 101827-46-7
Butenafine is a synthetic benzylamine antifungal. It is structurally related to synthetic allylamine antifungals such as terbinafine. Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes. Lacking ergosterol, the cell membranes increase in permeability, allowing their contents to leak out. Furthermore, inhibition of squalene epoxidase leads to a toxic buildup of squalene. This double action of butenafine (increased membrane permeability and toxic buildup of squalene) makes butenafine fungicidal rather than merely fungistatic.
Name: Butenafine HCl
CAS#: 101827-46-7 (HCl)
Chemical Formula: C23H28ClN
Exact Mass: 317.21435
Molecular Weight: 353.934
Elemental Analysis: C, 78.05; H, 7.97; Cl, 10.02; N, 3.96
Related CAS #: 101828-21-1 (free base) 101827-46-7 (HCl)
Synonym: Butenafine, Mentax, Butop, KP363, KP 363, KP-363
IUPAC/Chemical Name: 1-Naphthalenemethanamine, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-, hydrochloride
InChi Key: LJBSAUIFGPSHCN-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
SMILES Code: CN(CC1=CC=C(C(C)(C)C)C=C1)CC2=C3C=CC=CC3=CC=C2.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001