CUDC-101, CAS 1012054-59-9

  • CUDC-101, CAS 1012054-59-9

CUDC-101, CAS 1012054-59-9
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  • CAS Number: 1012054-59-9
  • Stock: 1.65kg
  • Assay: 98.73%

CUDC-101, CAS 1012054-59-9

CUDC-101, CAS 1012054-59-9Stock 1648g, Assay 98.73%, White powderWater 0.45%, Single Impurity 0.35%.


CUDC-101

CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC.


Product Details:

Name: CUDC-101

CAS#: 1012054-59-9

Chemical Formula: C24H26N4O4

Exact Mass: 434.19541

Molecular Weight: 434.49

Elemental Analysis: C, 66.34; H, 6.03; N, 12.89; O, 14.73


Specification:

Synonym: CUDC101; CUDC 101; CUDC-101.

IUPAC/Chemical Name: 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide

InChi Key: PLIVFNIUGLLCEK-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)

SMILES Code: O=C(NO)CCCCCCOC1=CC2=C(NC3=CC=CC(C#C)=C3)N=CN=C2C=C1OC

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: