CAS 101020-89-7: Artemisitene

  • CAS 101020-89-7: Artemisitene

CAS 101020-89-7: Artemisitene
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  • CAS Number: 101020-89-7
  • Stock: 287g
  • Assay: 99.50%

Artemisitene, CAS 101020-89-7

Artemisitene, CAS 101020-89-7, Stock 285g, Assay 99.5%, White powder, Water 0.45%, Single Impurity 0.5%.


Artemisitene

Artemisitene, also known as ATT, is an antimalarial agent and the oxidized form of Artemisinin. Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway. Artemisitene (ATT) is a natural derivative of the antimalarial drug artemisinin, selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. ATT effectively kills human cancer cells without apparent cytotoxicity on normal human cells or mouse liver and kidney. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4.


Product Details:

Name: Artemisitene

CAS#: 101020-89-7

Chemical Formula: C15H20O5

Exact Mass: 280.1311

Molecular Weight: 280.32

Elemental Analysis: C, 64.27; H, 7.19; O, 28.54


Specification:

Synonym: (+)-Artemisitene; Artemisitene; Dehydroqinghaosu; Methenyl-artemisinin; ATT.

IUPAC/Chemical Name: 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one, octahydro-3,6-dimethyl-9-methylene-, (3R-(3alpha,5abeta,6beta,8abeta,12beta,12aR*))-

InChi Key: IGEBZMMCKFUABB-MHVOBNHCSA-N

InChi Code: 1S/C15H20O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8,10-11,13H,2,4-7H2,1,3H3/t8-,10+,11?,13-,14-,15-/m1/s1

SMILES Code: C[C@@H]1CC[C@@H]2C(=C)C(=O)O[C@H]3[C@@]42OO[C@@](O3)(CC[C@@H]14)C

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: