MK-510, CAS 1010085-13-8

MK-510, CAS 1010085-13-8, Stock 382g, Assay 99.6%, White powder, Water 0.12%, Single Impurity 0.4%.

MK-510

MK-5108, also known as VX689, is a novel small molecule with potent inhibitory activity against Aurora-A kinase. MK-5108 specifically inhibited Aurora-A kinase in a panel of protein kinase assays. MK-5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. MK-5108 inhibited growth of human tumor cell lines in culture and in different xenograft models. MK-5108 is currently tested in clinical trials and offers a new therapeutic approach to combat human cancers as a single agent or in combination with existing taxane therapies. (source: Mol Cancer Ther. 2010 Jan;9(1):157-66. Epub 2010 Jan 6.).

Product Details:

Name: MK-5108

CAS#: 1010085-13-8

Chemical Formula: C22H21ClFN3O3S

Exact Mass: 461.09762

Molecular Weight: 461.94

Elemental Analysis: C, 57.20; H, 4.58; Cl, 7.67; F, 4.11; N, 9.10; O, 10.39; S, 6.94

Specification:

Synonym: MK5108; MK-5108; MK 5108; VX689; VX 689; VX-689.

IUPAC/Chemical Name: (1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxylic acid

InChi Key: LCVIRAZGMYMNNT-VVONHTQRSA-N

InChi Code: InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22-

SMILES Code: O=C([C@@]1(CC2=NC(NC3=NC=CS3)=CC=C2)CC[C@H](OC4=CC=CC(Cl)=C4F)CC1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: soluble in DMSO, not soluble in water.

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

HS Tariff Code: 2934.99.9001

Certification: