CAS 1005402-19-6: Irdabisant

Irdabisant, CAS 1005402-19-6, Stock 259g, Assay 99.7%, White powder, Water 0.19%, Single Impurity 0.3%.

Irdabisant

Irdabisant, also known as CEP-26401, is a potent, selective histamine H3 receptor inverse agonist. High affinity of CEP-26401 for H₃R was demonstrated in radioligand binding displacement assays in rat brain membranes (K(i) = 2.7 ± 0.3 nM) and recombinant rat and human H₃R-expressing systems (K(i) = 7.2 ± 0.4 and 2.0 ± 1.0 nM, respectively). CEP-26401 displayed potent antagonist and inverse agonist activities in [³⁵S]guanosine 5'-O-(γ-thio)triphosphate binding assays. CEP-26401 may also have therapeutic utility in treating schizophrenia or as adjunctive therapy to approved antipsychotics.

Product Details:

Name: Irdabisant

CAS#: 1005402-19-6 (free base)

Chemical Formula: C18H23N3O2

Exact Mass: 313.179

Molecular Weight: 313.401

Elemental Analysis: C, 68.98; H, 7.40; N, 13.41; O, 10.21

Specification:

Synonym: CEP-26401; CEP 26401; CEP26401; Irdabisant

IUPAC/Chemical Name: (R)-6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)pyridazin-3(2H)-one

InChi Key: XUKROCVZGZNGSI-CQSZACIVSA-N

InChi Code: InChI=1S/C18H23N3O2/c1-14-4-2-11-21(14)12-3-13-23-16-7-5-15(6-8-16)17-9-10-18(22)20-19-17/h5-10,14H,2-4,11-13H2,1H3,(H,20,22)/t14-/m1/s1

SMILES Code: O=C1C=CC(C2=CC=C(OCCCN3[C@H](C)CCC3)C=C2)=NN1

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: