Tazemetostat, 1403254-99-8, Stock 270g, World biggest supplier.

Tazemetostat, 1403254-99-8, Stock270g, World biggest supplier.

Tazemetostat, 1403254-99-8, HPLC 99.55%, HNMR, MASS, HPLC, COA, MSDS we supply.

Tazemetostat, 1403254-99-8, batch size 1kg, White powder.

Tazemetostat, also known as EPZ-6438 and E7438, is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1 mutant MRTs on EZH2 enzymatic activity and portend the utility of EZH2-targeted drugs for the treatment of these genetically defined cancers.





Name: Tazemetostat

CAS#: 1403254-99-8

Chemical Formula: C34H44N4O4

Exact Mass: 572.33626

Molecular Weight: 572.74

Elemental Analysis: C, 71.30; H, 7.74; N, 9.78; O, 11.17


Synonym: EPZ-6438; EPZ 6438; EPZ6438; E7438; E-7438; E 7438; Tazemetostat

IUPAC/Chemical Name: N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

InChi Key: NSQSAUGJQHDYNO-UHFFFAOYSA-N

InChi Code: InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)

SMILES Code: O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001




EOS Med Chem, Medicinal Chemical is Big

執大象,天下往,往而無害,安平泰

 

My GMP plant, pls visit youtube: https://youtu.be/VoAKzYsgH5Q.

Add: Shanghe Pharma-Chem Park, Jinan City.

This is my R&D youtube: https://youtu.be/r5cJdXKNXHk. 

Add: Jinan Life Sience Park 4# Building.

 

E: info@eosmedchem.com 

W: www.eosmedchem.com 

Tel: 0086-531-69905422

SALE OFFICE: 16F, China Overseas Plaza, Jinan City, China