15811099 CAS 714272-27-2: Plinabulin

CAS 714272-27-2: Plinabulin

  • CAS 714272-27-2: Plinabulin

CAS 714272-27-2: Plinabulin
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 714272-27-2
  • Stock: 322g
  • Assay: 98.31%

Plinabulin, CAS 714272-27-2

Plinabulin, CAS 714272-27-2, Stock 322g, Assay 98.31%, White powder, Water 0.23%, Single Impurity 0.31%.


Plinabulin

Plinabulin is a VDA of novel structure in having been derived from a marine microbial source, as opposed to terrestrial sources for other VDAs. Plinabulin binds to the colchicine binding site of b-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. Plinabulin has been shown to produce anti-tumor activity in animal models as a single agent and synergistically with other chemotherapy agents including taxanes. Overall, preclinical studies indicated plinabulin had a favorable safety and activity profile leading to the initiation of clinical trials. Favorable data from early clinical studies lead to the initiation of a Phase 2 clinical trial program.


Product Details:

Name: Plinabulin

CAS#: 714272-27-2

Chemical Formula: C19H20N4O2

Exact Mass: 336.15863

Molecular Weight: 336.39

Elemental Analysis: C, 67.84; H, 5.99; N, 16.66; O, 9.51




Specification:

Synonym: NPI 2358; NPI2358; NPI-2358; Plinabulin

IUPAC/Chemical Name: (3E,6E)-3-benzylidene-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione

InChi Key: UNRCMCRRFYFGFX-AOEKMSOUSA-N

InChi Code: InChI=1S/C19H20N4O2/c1-19(2,3)16-13(20-11-21-16)10-15-18(25)22-14(17(24)23-15)9-12-7-5-4-6-8-12/h4-11H,1-3H3,(H,20,21)(H,22,25)(H,23,24)/b14-9+,15-10+

SMILES Code: O=C(/C(NC/1=O)=C\C2=CC=CC=C2)NC1=C\C3=C(C(C)(C)C)NC=N3

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

HS Tariff Code: 2934.99.9001


Certification: