CAS 57103-68-1: Maytansinol
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- CAS Number: 57103-68-1
- Stock: 820g
- Assay: 99.35%
CAS 57103-68-1: Maytansinol
CAS 57103-68-1: Maytansinol, Stock 820g, Assay 98.66%, White powder, Water 0.4%, Single Impurity 0.67%.
Maytansinol
Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent. Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol is used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity.
Product Details:
Name: Maytansinol
CAS#: 57103-68-1
Chemical Formula: C28H37ClN2O8
Exact Mass: 564.2238
Molecular Weight: 565.06
Elemental Analysis: C, 59.52; H, 6.60; Cl, 6.27; N, 4.96; O, 22.65
Specification:
Related CAS #: 57103-68-1
Synonym: Maytansinol; Ansamitocin P-0; Ansamitocin P 0; Antibiotic C 15003P 0; NSC 239386; NSC-239386; NSC239386; maytansine derivative;
IUPAC/Chemical Name: (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14,4-dihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-diene-12,6-dione
InChi Key: QWPXBEHQFHACTK-RZKXNLMUSA-N
InChi Code: InChI=1S/C28H37ClN2O8/c1-15-8-7-9-22(37-6)28(35)14-20(38-26(34)30-28)16(2)25-27(3,39-25)21(32)13-23(33)31(4)18-11-17(10-15)12-19(36-5)24(18)29/h7-9,11-12,16,20-22,25,32,35H,10,13-14H2,1-6H3,(H,30,34)/b9-7+,15-8+/t16-,20+,21+,22-,25+,27+,28+/m1/s1
SMILES Code: O=C1O[C@@]([C@@H](C)[C@H]2[C@](C)([C@@H](O)CC3=O)O2)([H])C[C@@]([C@H](OC)/C=C/C=C(CC4=CC(OC)=C(Cl)C(N3C)=C4)\C)(O)N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Certifications:
