CAS 1355326-35-0: AGI-5198
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AGI-5198, CAS 1355326-35-0

AGI-5198, CAS 1355326-35-0, Stock 1375g, Assay 98.48%, White powder, Water 0.28%, Single Impurity 0.19%.

AGI-5198

AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity. AGI-5198 shows good potency in the U87 R132H cell based assay and ~90% tumor 2-HG inhibition in the corresponding mouse xenograft model following BID dosing. AGI-5198 inhibits IDH1 R132H mutant and R132C mutant in vitro with IC50 ~0.07 μM and ~0.16 μM, respectively.

Product Details:

Name: AGI-5198

CAS#: 1355326-35-0

Chemical Formula: C27H31FN4O2

Exact Mass: 462.2431

Molecular Weight: 462.55904

Elemental Analysis: C, 70.11; H, 6.76; F, 4.11; N, 12.11; O, 6.92

Specification:

Synonym: AGI5198; AGI-5198; AGI 5198; IDHC35; IDH-C35; IDH C35.

IUPAC/Chemical Name: N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide

InChi Key: FNYGWXSATBUBER-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,18H2,1-2H3,(H,30,34)

SMILES Code: O=C(NC1CCCCC1)C(N(C2=CC=CC(F)=C2)C(CN3C=CN=C3C)=O)C4=CC=CC=C4C

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: