CAS 129453-61-8: Fulvestrant

  • CAS 129453-61-8: Fulvestrant

CAS 129453-61-8: Fulvestrant
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 129453-61-8
  • Stock: 237g
  • Assay: 99.50%

Fulvestrant, CAS 129453-61-8

Fulvestrant, CAS 129453-61-8, Stock 237g, Assay 99.50%, White powder, Water 0.29%, Single Impurity 0.21%.


Fulvestrant

Fulvestrant is a synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines.


Product Details:

Name: Fulvestrant

CAS#: 129453-61-8

Chemical Formula: C32H47F5O3S

Exact Mass: 606.31661

Molecular Weight: 606.77

Elemental Analysis: C, 63.34; H, 7.81; F, 15.66; O, 7.91; S, 5.28


Specification:

Synonym: ZD9238; ZD-9238; ZD 9238; ICI 182780; ICI182780; ICI-182780; ZM182780; ZM 182780; ZM-182780; Fulvestrant ; Faslodex.

IUPAC/Chemical Name: (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

InChi Key: VWUXBMIQPBEWFH-WCCTWKNTSA-N

InChi Code: InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1

SMILES Code: OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])[C@H](CCCCCCCCCS(CCCC(F)(F)C(F)(F)F)=O)CC2=C1

Appearance: white to off-white solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: