CAS 1265917-14-3: E-52862 HCl
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E-52862 HCl, CAS 1265917-14-3

E-52862 HCl, CAS 1265917-14-3, Stock 360g, Assay 99.29%, White powder, Water 0.35%, Single Impurity 0.36%.

E-52862 HCl

E-52862, also known as S1RA and MR390, is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 17.0 ± 7.0 nM, selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state. E-52862 attenuates neuropathic pain of different aetiology in rats.

Product Details:

Name: E-52862 HCl

CAS#: 1265917-14-3 (HCl)

Chemical Formula: C20H24ClN3O2

Exact Mass:

Molecular Weight: 373.88

Elemental Analysis: C, 64.25; H, 6.47; Cl, 9.48; N, 11.24; O, 8.56

Specification:

Synonym: E-52862; E 52862; E52862; S1RA; E-52862 HCl; E-52862 hydrochloride; S1RA hydrochloride; MR390; MR 390; MR-390;

IUPAC/Chemical Name: 4-(2-((5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yl)oxy)ethyl)morpholine hydrochloride

InChi Key: SHRYQZBTQDMGLZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23N3O2.ClH/c1-16-14-20(25-13-10-22-8-11-24-12-9-22)21-23(16)19-7-6-17-4-2-3-5-18(17)15-19;/h2-7,14-15H,8-13H2,1H3;1H

SMILES Code: CC1=CC(OCCN2CCOCC2)=NN1C3=CC=C4C=CC=CC4=C3.[H]Cl

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: