CAS 159857-81-5: MC-Val-Cit-PAB-PNP
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- CAS Number: 159857-81-5
- Stock: 236g
- Assay: 99.12%
MC-Val-Cit-PAB-PNP, CAS 159857-80-4:
MC-Val-Cit-PAB-PNP, CAS 159857-81-5, Stock 236g, Assay 99.12%, White powder, Water 0.25%, Single Impurity 0.17%.
MC-Val-Cit-PAB-PNP
MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. The Val-Cit will specifically be cleaved by catepsin B. Because this enzyme is only present in the lysosome, the ADC payload will only be released in the cell. The Azido group will react with DBCO, BCN or other Alkyne groups through click chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. * * * * * * Please also see similar products: #610235: MC-Val-Cit-PAB (ADC peptide linker) and #610234: MC-Val-Cit-PAB-PNP (ADC peptide linker); #620108 Val-cit-PAB-OH (ADC peptide linker).
Product Details:
Name: MC-Val-Cit-PAB-PNP
CAS#: 159857-81-5 (MC-Val-Cit-PAB-PNP)
Chemical Formula: C35H43N7O11
Exact Mass: 737.3021
Molecular Weight: 737.767
Elemental Analysis: C, 56.98; H, 5.88; N, 13.29; O, 23.85
Specification:
Related CAS #: 159857-80-4 (MC-Val-Cit-PAB) 159857-81-5 (MC-Val-Cit-PAB-PNP) 159857-79-1 (Val-cit-PAB-OH)
Synonym: MC-Val-Cit-PAB-PNP; Mc-Val-Cit-PABC-PNP; Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate. Mc-Val-Cit-PAB
IUPAC/Chemical Name: 4-((S)-N-((S)-1-amino-1-oxo-5-ureidopentan-2-yl)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)benzyl (4-nitrophenyl) carbonate
InChi Key: UQRQGHMQKAXOTE-DHIFEGFHSA-N
InChi Code: InChI=1S/C35H43N7O11/c1-22(2)31(39-28(43)8-4-3-5-20-40-29(44)17-18-30(40)45)33(47)41(27(32(36)46)7-6-19-38-34(37)48)24-11-9-23(10-12-24)21-52-35(49)53-26-15-13-25(14-16-26)42(50)51/h9-18,22,27,31H,3-8,19-21H2,1-2H3,(H2,36,46)(H,39,43)(H3,37,38,48)/t27-,31-/m0/s1
SMILES Code: O=C([C@@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(C)C)=O)CCCNC(N)=O)NC2=CC=C(C=C2)COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Certification:
