15811270 Detailed description of the CAS 1554458-53-5 : BAY1217389 - EOS Med Chem

CAS 1554458-53-5 : BAY1217389

CAS 1554458-53-5 : BAY1217389
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  • CAS Number: 1554458-53-5
  • Stock: 67g
  • Assay: 98.29%

BAY1217389, CAS 1554458-53-5:

BAY1217389, CAS 1554458-53-5, Stock 67g, Assay 98.29%, White powder, Water 0.17%, Single Impurity 0.31%.


BAY1217389, CAS 1554458-53-5

BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells.


Product Details:

Name: BAY1217389

CAS#: 1554458-53-5

Chemical Formula: C27H24F5N5O3

Exact Mass: 561.1799

Molecular Weight: 561.513

Elemental Analysis: C, 57.75; H, 4.31; F, 16.92; N, 12.47; O, 8.55




Specification:

Synonym: BAY1217389; BAY-1217389; BAY 1217389.

IUPAC/Chemical Name: N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide

InChi Key: WNEILUNVMHVMPH-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38)

SMILES Code: O=C(NC1CC1)C2=CC=C(C3=CN=C4C(NCCC(F)(F)F)=CC(OC5=CC=C(OC)C(F)=C5F)=NN43)C=C2C

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: