15811245 Explanation details of CAS 1550008-55-3 : ML-264 - eos med chem

CAS 1550008-55-3 : ML-264

CAS 1550008-55-3 : ML-264
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  • CAS Number: 1550008-55-3
  • Stock: 129g
  • Assay: 98.32%

ML-264, CAS 1550008-55-3:

ML-264, CAS 1550008-55-3, Stock 129g, Assay 98.32%, White powder, Water 0.21%, Single Impurity 0.19%.


ML-264, CAS 1550008-55-3

ML-264 is a Krüppel-like factor 5 (KLF5) inhibitor That Potently Inhibits Growth of Colorectal Cancer. ML264 is highly active (IC50 = 29 nM is a cell-based assay for proliferation of DLD-1 cells, IC50 = 81 nM in a cell-based luciferase assay). It lacks cytotoxicity in the IEC-6 control cell line (IC50 >50 μM, <50% inhibition was observed at 100 μM). Robust activity was also seen in several other KLF5-expressing cell types as well (e.g., HCT116, IC50 = 560 nM; HT29, IC50 = 130 nM; SW620, IC50 = 430 nM). ML264 is a good candidate for in vivo anticancer studies, with great potential for use in long time-course in situ studies aimed to elucidate the role of KLF5 as a regulator of cellular proliferation and tumor formation in the intestinal epithelium.


Product Details:

Name: ML-264

CAS#: 1550008-55-3

Chemical Formula: C17H21ClN2O4S

Exact Mass: 384.0911

Molecular Weight: 384.875

Elemental Analysis: C, 53.05; H, 5.50; Cl, 9.21; N, 7.28; O, 16.63; S, 8.33



Specification:

Synonym: ML-264; ML264; ML 264; CID-51003603; SID 117686865, and SR-03000002171.

IUPAC/Chemical Name: (E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)(methyl)amino)-2-oxoethyl)acrylamide

InChi Key: AJCDZIDKYKCOMZ-AATRIKPKSA-N

InChi Code: InChI=1S/C17H21ClN2O4S/c1-20(15-7-9-25(23,24)10-8-15)17(22)12-19-16(21)6-5-13-3-2-4-14(18)11-13/h2-6,11,15H,7-10,12H2,1H3,(H,19,21)/b6-5+

SMILES Code: O=C(NCC(N(C(CC1)CCS1(=O)=O)C)=O)/C=C/C2=CC=CC(Cl)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: