Simufilam, CAS 1224591-33-6

Simufilam, CAS 1224591-33-6, Stock 429g, Assay 99.5%, White powder, Water 0.54%, Single Impurity 0.5%.

Simufilam

Simufilamum, also known as PTI-125, is a filamin A altered conformations binder. PTI-125 is an oral small molecule drug candidate that binds and reverses an altered conformation of the scaffolding protein filamin A found in Alzheimer's disease brain. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. PTI-125 also reduced tau hyperphosphorylation, aggregated Aβ42 deposition, neurofibrillary tangles, and neuroinflammation. Efficacy in postmortem AD and Aβ42-treated age-matched control hippocampal slices was concentration-dependent starting at 1 picomolar (pM) concentration. PTI-125 is the first therapeutic candidate to preferentially bind an altered protein conformation and reverse this proteopathy.

Product Details:

Name: Simufilamum

CAS#: 1224591-33-6

Chemical Formula: C15H21N3O

Exact Mass: 259.1685

Molecular Weight: 259.35

Elemental Analysis: C, 69.47; H, 8.16; N, 16.20; O, 6.17

Specification:

Synonym: simufilamum; simufilam; PTI125; PTI 125; PTI-125

IUPAC/Chemical Name: 1-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one

InChi Key: BSQPTZYKCAULBH-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H21N3O/c1-17-9-7-15(8-10-17)16-11-14(19)18(15)12-13-5-3-2-4-6-13/h2-6,16H,7-12H2,1H3

SMILES Code: O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

HS Tariff Code: 2934.99.9001

Certification: