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CAS Number：1092364-38-9
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SMILES：Poziotinib (HM-781-36) , CAS 1092364-38-9Poziotinib, CAS?1092364-38-9,?Stock?320g,?Assay?99.5%,?White powder, Water?0.16%,?Single Impurity?0.5%.PoziotinibPoziotinib , also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival.Product Details:Name: PoziotinibCAS#: 1092364-38-9 (free base)Chemical Formula: C23H21Cl2FN4O3Exact Mass: 490.09747Molecular Weight: 491.34Elemental Analysis: C, 56.22; H, 4.31; Cl, 14.43; F, 3.87; N, 11.40; O, 9.77Specification:Synonym:?HM781-36B; HM78136B; HM-78136B; HM 78136B; NOV120101; NOV-120101; NOV 120101; PoziotinibIUPAC/Chemical Name:?1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-oneInChi Key:?LPFWVDIFUFFKJU-UHFFFAOYSA-NInChi Code:?InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)SMILES Code:?C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=OAppearance:?Pale yellow solid powderPurity:?>98% (or refer to the Certificate of Analysis)Shipping Condition:?Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition:?Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility:?Soluble in DMSO, not in waterShelf Life:?>2 years if stored properlyDrug Formulation:?This drug may be formulated in DMSOHS Tariff Code:?2934.99.9001Certification: