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CAS Number：130549-04-1
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SMILES：CAS 130549-04-1 is a chemical compound known as sitagliptin phosphate. It is an oral medication that belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors and is primarily used in the management of type 2 diabetes mellitus.Sitagliptin phosphate is a white to off-white powder that is soluble in water. Its chemical formula is C16H15F6N5O??H3PO4, and it is available in tablet form for oral administration.One of the main uses of CAS 130549-04-1 is to help control blood sugar levels in individuals with type 2 diabetes. Sitagliptin phosphate works by inhibiting the enzyme DPP-4, which breaks down incretin hormones such as glucagon-like peptide-1 (GLP-1). By inhibiting DPP-4, sitagliptin increases the levels of GLP-1, which stimulates insulin secretion from pancreatic beta cells and reduces the production of glucagon. This mechanism leads to improved glycemic control and helps lower blood glucose levels.Additionally, sitagliptin phosphate can be used either alone or in combination with other antidiabetic medications, such as metformin or sulfonylureas, to achieve optimal blood sugar control. It is often prescribed when lifestyle modifications, including diet and exercise, have not been sufficient in managing blood glucose levels.It is important to note that sitagliptin phosphate should be used under medical supervision, and dosage adjustments may be necessary based on individual patient factors. Common side effects may include headache, upper respiratory tract infections, and gastrointestinal disturbances. Rare but serious side effects, such as pancreatitis and severe allergic reactions, have been reported and should be monitored by healthcare professionals.In conclusion, CAS 130549-04-1, or sitagliptin phosphate, is a medication used in the treatment of type 2 diabetes mellitus. It helps control blood sugar levels by inhibiting DPP-4 and increasing the activity of GLP-1 hormones. However, it should be used under medical supervision, and patients should be aware of potential side effects. Regular monitoring and adherence to a comprehensive diabetes management plan are essential for optimal outcomes.