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CAS Number：656247-17-5
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SMILES：Nintedanib (Bibf 1120), CAS 656247-17-5Nintedanib (Bibf 1120), CAS 656247-17-5,?Stock?661g,?Assay?98.61%,?White powder,?Water?0.24%,?Single Impurity?0.32%.BIBF 1120Nintedanib, also known as BIBF 1120, is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR). Intedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration. On 11/15/2014 , FDA approved Nintedanib for the treatment of idiopathic pulmonary fibrosis (IPF).Product Details:Name: NintedanibCAS#: 656247-17-5 (free base)Chemical Formula: C31H33N5O4Exact Mass: 539.25325Molecular Weight: 539.62Elemental Analysis: C, 69.00; H, 6.16; N, 12.98; O, 11.86Specification:Related CAS #: 656247-18-6 (esylate)? ?656247-17-5 (free base)? ?928326-83-4 (free base)? ??Synonym: BIBF1120; BIBF 1120; BIBF-1120; Nintedanib. Brand name: Vargatef.IUPAC/Chemical Name: (Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylateInChi Key: XZXHXSATPCNXJR-ZIADKAODSA-NInChi Code: InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-SMILES Code: O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)OCAppearance: white powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSO, not in waterShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: