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CAS Number：700874-72-2
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SMILES：LY2157299,Galunisertib , CAS 700874-72-2LY2157299,Galunisertib, CAS?700874-72-2,?Stock?1463g,?Assay?98.43%,?White powder,?Water?0.73%,?Single Impurity?0.26%.LY2157299,GalunisertibGalunisertib, also known as LY2157299, is a novel, selective small molecule transforming growth factor beta receptor (TGF-??R) kinase inhibitor. LY2157299 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independently of the expression levels of TGF-??RII.Product Details:Name: GalunisertibCAS#: 700874-72-2 (free base)Chemical Formula: C22H19N5OExact Mass: 369.15896Molecular Weight: 369.42Elemental Analysis: C, 71.53; H, 5.18; N, 18.96; O, 4.33Specification:Synonym: LY2157299; LY-2157299; LY 2157299; GalunisertibIUPAC/Chemical Name: 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamideInChi Key: IVRXNBXKWIJUQB-UHFFFAOYSA-NInChi Code: InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)SMILES Code: O=C(C1=CC=C2N=CC=C(C3=C(CCC4)N4N=C3C5=NC(C)=CC=C5)C2=C1)NAppearance: White powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSO, not in waterShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certifications: