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CAS Number：869886-67-9
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SMILES：VRT752271, CAS 869886-67-9VRT752271, CAS 869886-67-9,?Stock?811g,?Assay?98.64%,?White powder,?Water?0.24%,?Single Impurity?0.32%.Ulixertinib (BVD-523)Ulixertinib, also known as BVD-523 and VRT752271, is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.Product Details:Name: Ulixertinib (BVD-523)CAS#: 869886-67-9 (free base)Chemical Formula: C21H22Cl2N4O2Exact Mass: 432.11198Molecular Weight: 433.33Elemental Analysis: C, 58.21; H, 5.12; Cl, 16.36; N, 12.93; O, 7.38Specification:Related CAS #: 869886-67-9 (free base)? ?1956366-10-1 (HCl)? ?1975172-95-2 (HCl hydrate)? ??Synonym: BVD-523, BVD 523, BVD523, VRT752271, VRT752271, VRT 752271, UlixertinibIUPAC/Chemical Name: (S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide.InChi Key: KSERXGMCDHOLSS-LJQANCHMSA-NInChi Code: InChI=1S/C21H22Cl2N4O2/c1-12(2)26-20-8-16(17(23)10-25-20)14-7-18(24-9-14)21(29)27-19(11-28)13-4-3-5-15(22)6-13/h3-10,12,19,24,28H,11H2,1-2H3,(H,25,26)(H,27,29)/t19-/m1/s1SMILES Code: O=C(C1=CC(C2=CC(NC(C)C)=NC=C2Cl)=CN1)N[C@@H](C3=CC=CC(Cl)=C3)COAppearance: White powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSO, not in waterShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: