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CAS Number：1252594-99-2
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SMILES：ETP-46321, CAS 1252594-99-2ETP-46321, CAS?1252594-99-2,?Stock?250g,?Assay?99.15%,?White powder,EOS Med Chem is big manufacturer of?ETP-46321ETP-46321ETP-46321 is a potent and orally bioavailable PI3K ??, ?? inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing. ETP-46321 PK/PD studies showed time dependent downregulation of AKT(Ser473) phosphorylation, which correlates with compound levels in tumor tissue and demonstrating to be efficacious in a GEMM mouse tumor model driven by a K-Ras(G12V) oncogenic mutation. Treatment with ETP-46321 resulted in significant tumor growth inhibition.Product Details:Name: ETP-46321CAS#: 1252594-99-2Chemical Formula: C20H27N9O3SExact Mass: 473.19576Molecular Weight: 473.55Elemental Analysis: C, 50.73; H, 5.75; N, 26.62; O, 10.14; S, 6.77Specification:Synonym: ETP46321; ETP-46321; ETP 46321IUPAC/Chemical Name: 5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amineInChi Key: OHKDVDMWRKFZRB-UHFFFAOYSA-NInChi Code: InChI=1S/C20H27N9O3S/c1-33(30,31)29-4-2-26(3-5-29)12-16-13-28-14-17(15-10-22-20(21)23-11-15)25-19(18(28)24-16)27-6-8-32-9-7-27/h10-11,13-14H,2-9,12H2,1H3,(H2,21,22,23)SMILES Code: NC1=NC=C(C2=CN3C(C(N4CCOCC4)=N2)=NC(CN5CCN(S(=O)(C)=O)CC5)=C3)C=N1Appearance: Solid powderPurity: >99% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSO, not in waterShelf Life: >5 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certifications: