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CAS Number：1610964-64-1
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SMILES：???β??֣?CAS 1610964-64-1Unesbulin??CAS 1610964-64-1??ԭҺ?680g??????99.20%????????ĩ??ˮ0.18%????һ????0.20%???????????˹????Unesbulin Ҳ??Ϊ PTC-596???? B ϸ????????Ī????????Ѫ??????????λ?? 1 (BMI1) ?????Ƽ???BMI1 ?Ƕ??????Ƹ????? 1 (PRC1) ?ij?Ա???ڻ?????Ĭ?з??????á??????? MOLM-13 ???????԰?Ѫ?? (AML) ?? Rec-1 ??ϸ???ܰ??? (MCL) ??ϸ??????ֳ??IC50 ?ֱ? = 22.4 ?? 136 nM???????????յ???ͬϸ???е? BMI1 ??????ϸ???????? PTC-596 ???? MM.1S ?෢?Թ?????ϸ???е?΢?ܾۺϲ??յ?ϸ??????ͣ???? G2/M ?ڡ????????? Rec-1 ϸ???в?Ⱥϸ????????????Ⱥϸ????һ?־??и?ϸ?????????Ķ???ϸ??Ⱥ (IC50 = 138 nM)?? PTC-596??5 mg/kg???ڷ????????? MOLM-13 С????????ֲģ?͵Ĵ????ʡ???Ʒ???飺????: Unesbulin ??????CAS#??1610964-64-1?????????ѧʽ??C19H13F5N6??ȷ??????420.11????????420.347Ԫ?ط?????C??54.29?? H??3.12?? F??22.60?? N, 19.99??????ͬ???ʣ? PTC596?? PTC-596?? PTC 596??????˹???֣?IUPAC/??ѧ???ƣ? 5-??-2-(6-??-2-?׻?-1H-????[d]????-1-??)-N4-(4-(?????׻?)????)????-4,6-????InChi ??Կ?? TWLWOOPCEXYVBE-UHFFFAOYSA-NInChi???룺 InChI=1S/C19H13F5N6/c1-9-26-13-7-4-11(20)8-14(13)30(9)18-28-16(25)15(21)17(29) -18)27-12-5-2-10(3-6-12)19(22,23)24/h2-8H,1H3,(H3,25,27,28,29)΢Ц???룺 NC1=C(F)C(NC2=CC=C(C(F)(F)F)C=C2)=NC(N3C(C)=NC4=CC=C(F)C=C34) =N1???ۣ???????ĩ???ȣ? >98%?????ο?????֤?飩????????????Ϊ??Σ?ջ?ѧƷ?ڻ????¶??????䡣?ò?Ʒ???????????ͺ???ͣ???ڼ??ļ??????㹻?ȶ?????????????????ܹ⣬0 - 4 C ???ڣ??????????ܣ??? -20 C ???ڣ??????????꣩???ܽ??ȣ?????DMSO?????ڣ??????????õ???>3??ҩ???Ƽ?????ҩ???????? DMSO ???ƿ?????Һ???棺 0 - 4 C ???ڣ??????????ܣ?????-20 C ???ڣ????£??????ع?˰???룺 2934.99.9001