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CAS Number：1802425-99-5
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SMILES：CAS 1802425-99-5: MilvexianCAS 1802425-99-5: Milvexian,?Stock?300g,?Assay?99.2%,?White powder, Water?0.27%.MilvexianMilvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikrein??Ki = 44 nM (400-fold selective), and chymotrypsin??Ki = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overall exposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%.Product Details:Name: MilvexianCAS#: 1802425-99-5 (free base)Chemical Formula: C28H23Cl2F2N9O2Exact Mass: 625.13Molecular Weight: 626.450Elemental Analysis: C, 53.68; H, 3.70; Cl, 11.32; F, 6.07; N, 20.12; O, 5.11Specification:Synonym: Milvexian; BMS-986177; BMS 986177; BMS986177; JNJ-70033093; JNJ 70033093; JNJ70033093;IUPAC/Chemical Name: (5R,9S)-9-(4-(5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl)-6-oxo-1l4,6l5-pyrimidin-1-yl)-21-(difluoromethyl)-5-methyl-21H-3-aza-1(4,2)-pyridina-2(5,4)-pyrazolacyclononaphan-4-oneInChi Key: FSWFYCYPTDLKON-CMJOXMDJSA-NInChi Code: InChI=1S/C28H23Cl2F2N9O2/c1-15-3-2-4-23(20-9-16(7-8-33-20)26-21(36-27(15)43)12-35-41(26)28(31)32)39-14-34-19(11-25(39)42)18-10-17(29)5-6-22(18)40-13-24(30)37-38-40/h5-15,23,28H,2-4H2,1H3,(H,36,43)/t15-,23+/m1/s1SMILES Code: FC(F)N1N=CC(NC([C@H](C)CCC[C@@H]2[N]3=C(C=C(C4=CC(Cl)=CC=C4N5C=C(Cl)N=N5)N=C3)=O)=O)=C1C6=CC2=NC=C6Appearance: Solid powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSOShelf Life: >3 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001