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CAS Number：2851885-95-3
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SMILES：CAS 2851885-95-3: ARV-393CAS 2851885-95-3: ARV-393, Stock?720g,?Assay?98.85%,?White powder, Water?0.24%, Single Impurity?0.16%.ARV-393ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma.Product Details:Name:?ARV-393CAS#:?2851885-95-3Chemical Formula:?C46H53ClFN9O7Molecular Weight:?898.42Specification:SMILES Code:?ClC1=CN=C(N2CCC(O[C@@H]3C[C@@H](N4CCC(C5=C(F)C(CN(C6CCC(NC6=O)=O)C7=O)=C7C=C5)CC4)C3)CC2)N=C1NC8=CC(C=C(OCC(NC)=O)C(N9C(C)C)=O)=C9C=C8Appearance:?White? powderPurity:?>98% (or refer to the Certificate of Analysis)Shipping Condition:?Room temperature in continental US; may vary elsewhere.Storage Condition:?Please store the product under the recommended conditions in the Certificate of Analysis.Solubility:?Soluble in DMSO, not in waterShelf Life:?>2 years if stored properlyDrug Formulation:?This drug may be formulated in DMSOStock Solution Storage:?0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code:?2934.99.9001