CAS 1977495-97-8: Trilaciclib

  • CAS 1977495-97-8: Trilaciclib

CAS 1977495-97-8: Trilaciclib
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  • CAS Number: 1977495-97-8
  • Stock: 206g
  • Assay: 99.10%

Trilaciclib: CAS 1977495-97-8

Trilaciclib, CAS 1977495-97-8, Stock 206g, Assay 99.10%, White powder, EOS is one of TOP GMP manufacturer


Trilaciclib

Trilaciclib is a potential first-in-class short-acting CDK4/6 inhibitor in development to preserve hematopoietic stem cells and enhance immune system function during chemotherapy. Trilaciclib may help protect bone marrow cells from damage caused by chemotherapy by inhibiting cyclin-dependent kinase 4/6, a type of enzyme. Trilaciclib is the first therapy in its class and was approved for medical use in the United States in February 2021.


Product Details:

Name: Trilaciclib HCl
CAS#: 1977495-97-8 (HCl)
Chemical Formula: C24H32Cl2N8
Exact Mass: 518.2076
Molecular Weight: 519.475
Elemental Analysis: C, 55.49; H, 6.21; Cl, 13.65; N, 21.57; O, 3.08


Specification:

Related CAS #: 1374743-00-6 (free base)   1977495-97-8 (HCl)    
Synonym: Trilaciclib hydrochloride; G1T-28 hydrochloride; G1T 28 HCl; G1T28 HCl, Trilaciclib HCl;
IUPAC/Chemical Name: 2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one dihydrochloride
InChi Key: BRCYOXKEDFAUSA-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H30N8O.2ClH/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23;;/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29);2*1H
SMILES Code: O=C1C2=CC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=N4)N=C3N2C6(CCCCC6)CN1.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Code: 2934.99.9001

Certifications: