CAS 1025967-78-5: Lifitegrast
(World's Largest Pharmaceutical Supplier)
- CAS Number: 1025967-78-5
- Stock: 245g
- Assay: 99.70%
Lifitegrast, CAS 1025967-78-5
Lifitegrast, CAS 1025967-78-5, Stock 245g, Assay 99.7%, White powder, Water 0.53%, Single Impurity 0.3%.
Lifitegrast, also known as SAR-1118, is an LFA-1 antagonist intended for the treatment of vascular complications of the eye. Lifitegrast inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses.
CAS#: 1025967-78-5 (free base)
Chemical Formula: C29H24Cl2N2O7S
Exact Mass: 614.0681
Molecular Weight: 615.478
Elemental Analysis: C, 56.59; H, 3.93; Cl, 11.52; N, 4.55; O, 18.20; S, 5.21
Synonym: SAR-1118; SAR 1118; SAR1118; Lifitegrast, brand name: Xiidra.
IUPAC/Chemical Name: (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
InChi Key: JFOZKMSJYSPYLN-QHCPKHFHSA-N
InChi Code: InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1
SMILES Code: O=C(O)[C@@H](NC(C1=C(Cl)C2=C(CN(C(C3=CC=C4C=COC4=C3)=O)CC2)C=C1Cl)=O)CC5=CC=CC(S(=O)(C)=O)=C5
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001