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- CAS Number: 1855860-24-0
- Stock: 15g
- Assay: 99.20%
DS-1205B (1855860-24-0 (free base))
DS-1205B, 1855860-24-0 (free base), Stock 15g, World biggest supplier. EOS is the first 100g scale supplier.
DS-1205B, 1855860-24-0 (free base), HPLC 99.2%, HNMR, MASS, HPLC, COA, MSDS we supply.
DS-1205B, 1855860-24-0 (free base), batch size 100g, White powder.
DS-1205, also known as DS-1205b, is a selective and potent AXL kinase inhibitor with IC50 of 1.3 nM. DS-1205 potently inhibited the hGAS6-induced migration in vitro with EC50 of 2.7 nM. DS-1205b monotherapy exerted significant antitumor activity in an NIH3T3-AXL allograft model. In an HCC827 xenograft model, combination treatment with DS-1205b and osimertinib significantly delayed on the onset of tumor resistance compared to osimertinib alone in a manner proportional to DS-1205b does. DS-1205b also showed a similar resistance delay effect with erlotinib combination in the same xenograft model.
CAS#: 1855860-24-0 (free base)
Chemical Formula: C41H42FN5O7
Exact Mass: 735.3068
Molecular Weight: 735.8134
Elemental Analysis: C, 66.93; H, 5.75; F, 2.58; N, 9.52; O, 15.22
Synonym: DS-1205; DS 1205; DS1205; DS-1205b; DS 1205b; DS1205b; DS-1206b
IUPAC/Chemical Name: (R)-N-(4-(5-(4-((1,4-dioxan-2-yl)methoxy)-3-methoxyphenyl)-2-aminopyridin-3-yl)-3-fluorophenyl)-5-methyl-4'-oxo-1'-((tetrahydro-2H-pyran-4-yl)methyl)-1',4'-dihydro-[2,3'-bipyridine]-5'-carboxamide
InChi Key: ZOEILZXFYPPMTR-SSEXGKCCSA-N
InChi Code: InChI=1S/C41H42FN5O7/c1-25-3-7-36(44-18-25)33-21-47(20-26-9-11-51-12-10-26)22-34(39(33)48)41(49)46-29-5-6-31(35(42)17-29)32-15-28(19-45-40(32)43)27-4-8-37(38(16-27)50-2)54-24-30-23-52-13-14-53-30/h3-8,15-19,21-22,26,30H,9-14,20,23-24H2,1-2H3,(H2,43,45)(H,46,49)/t30-/m1/s1
SMILES Code: CC1=CC=C(C2=CN(CC3CCOCC3)C=C(C(NC4=CC=C(C5=C(N)N=CC(C6=CC(OC)=C(OC[C@@H]7OCCOC7)C=C6)=C5)C(F)=C4)=O)C2=O)N=C1
Appearance: Solid powder
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001