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- CAS Number: 1446711-81-4
- Stock: 268g
- Assay: 98.67%
Acoramidis (1446711-81-4), Stock 268kg, World biggest supplier.
Acoramidis (1446711-81-4), HPLC 98.67%, HNMR, MASS, HPLC, COA, MSDS we supply.
Acoramidis (1446711-81-4), batch size 1kg, White powder.
AG-10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. AG10 has been shown to stabilize Transthyretin (TTR or TBPA) --- a transport protein in serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol --- in Symptomatic Transthyretin Amyloid Cardiomyopathy. In this way, AG10 mimics a naturally occurring genetic variant, T119M, that protects from Transthyretin Amyloidosis.
Chemical Formula: C15H17FN2O3
Exact Mass: 292.1223
Molecular Weight: 292.31
Elemental Analysis: C, 61.63; H, 5.86; F, 6.50; N, 9.58; O, 16.42
Synonym: Acoramidis, AG-10, AG10, AG 10
IUPAC/Chemical Name: Benzoic acid, 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluoro-
InChi Key: WBFUHHBPNXWNCC-UHFFFAOYSA-N
InChi Code: 1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)
SMILES Code: Cc1n[nH]c(C)c1CCCOc2cc(ccc2F)C(=O)O
Appearance: White powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001