CAS 960203-27-4: Vortioxetine HBr
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- CAS Number: 960203-27-4
- Stock: 455g
- Assay: 99.34%
Vortioxetine HBr, CAS 960203-27-4
Vortioxetine HBr, CAS 960203-27-4, Stock 455g, Assay 99.34%, White powder, EOS Med Chem is big manufacturer of Vortioxetine HBr.
Vortioxetine HBr
Vortioxetine, also known as Lu AA21004, is an atypical antidepressant, and was approved in 2013 by the U.S. FDA for the treatment of major depressive disorder (MDD) in adults. Vortioxetine is a so-called "serotonin modulator and stimulator." It has been shown to possess the following pharmacological actions: Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) — Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM; Norepinephrine transporter (NET) blocker — Ki = 113 nM; 5-HT1A receptor high-efficacy partial agonist/near-full agonist — Ki = 15 nM, IA = 80%; 5-HT1B receptor partial agonist — Ki = 33 nM; 5-HT1D receptor antagonist — Ki = 54 nM; 5-HT3A receptor antagonist — Ki = 3.7 nM; 5-HT7 receptor antagonist — Ki = 19 nM.
Product Details:
Name: Vortioxetine HBr
CAS#: 960203-27-4 (HBr)
Chemical Formula: C18H23BrN2S
Exact Mass: 378.07653
Molecular Weight: 379.36
Elemental Analysis: C, 56.99; H, 6.11; Br, 21.06; N, 7.38; S, 8.45
Specification:
Related CAS #: 960203-27-4 (HBr) 508233-74-7 (free base) 1253056-29-9 (lactate)
Synonym: LuAA21004; LuAA 21004; LuAA-21004; Lu-AA21004; Lu AA21004; LuAA21004; AA21004; AA-21004; AA 21004; Vortioxetine, Vortioxetine Hydrobromide, Brintellix
IUPAC/Chemical Name: 1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine hydrobromide
InChi Key: InChI=1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
InChi Code: InChI=1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
SMILES Code: CC1=CC=C(SC2=CC=CC=C2N3CCNCC3)C(C)=C1.[H]Br
Appearance: White to off-white solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO.
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001