CAS 956697-53-3 : Sonidegib (LDE-225)

  • CAS 956697-53-3 : Sonidegib (LDE-225)

CAS 956697-53-3 : Sonidegib (LDE-225)
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  • CAS Number: 956697-53-3
  • Stock: 427g
  • Assay: 99.34%

Sonidegib (LDE-225) , CAS 956697-53-3

Sonidegib (LDE-225) , CAS 956697-53-3, Stock 427g, Assay 99.34%, White powderEOS Med Chem is big manufacturer of Sonidegib (LDE-225) .

Sonidegib (LDE-225) 

Sonidegib, also known as, erismodegib, LDE225, NVP-LDE225, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Erismodegib selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. It was approved by the FDA for treating basal cell carcinoma in July 2015.

Product Details:

Name: Sonidegib (LDE-225)

CAS#: 956697-53-3 (free base)

Chemical Formula: C26H26F3N3O3

Exact Mass: 485.19263

Molecular Weight: 485.49815

Elemental Analysis: C, 64.32; H, 5.40; F, 11.74; N, 8.66; O, 9.89


Related CAS #: 956697-53-3 (free base)   1218778-77-8 (phosphate)    

Synonym: LDE225; LDE 225; LDE-225; NVP-LDE225; NVP-LDE-225; NVP LDE225; Erismodegib; Sonidegib; Odomzo.

IUPAC/Chemical Name: N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide


InChi Code: InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+

SMILES Code: O=C(C1=C(C)C(C2=CC=C(OC(F)(F)F)C=C2)=CC=C1)NC3=CC=C(N4C[C@@H](C)O[C@@H](C)C4)N=C3

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001