CAS 956697-53-3 : Sonidegib (LDE-225)
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- CAS Number: 956697-53-3
- Stock: 427g
- Assay: 99.34%
Sonidegib (LDE-225) , CAS 956697-53-3
Sonidegib (LDE-225) , CAS 956697-53-3, Stock 427g, Assay 99.34%, White powder, EOS Med Chem is big manufacturer of Sonidegib (LDE-225) .
Sonidegib, also known as, erismodegib, LDE225, NVP-LDE225, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Erismodegib selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. It was approved by the FDA for treating basal cell carcinoma in July 2015.
Name: Sonidegib (LDE-225)
CAS#: 956697-53-3 (free base)
Chemical Formula: C26H26F3N3O3
Exact Mass: 485.19263
Molecular Weight: 485.49815
Elemental Analysis: C, 64.32; H, 5.40; F, 11.74; N, 8.66; O, 9.89
Related CAS #: 956697-53-3 (free base) 1218778-77-8 (phosphate)
Synonym: LDE225; LDE 225; LDE-225; NVP-LDE225; NVP-LDE-225; NVP LDE225; Erismodegib; Sonidegib; Odomzo.
IUPAC/Chemical Name: N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
InChi Key: VZZJRYRQSPEMTK-CALCHBBNSA-N
InChi Code: InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+
SMILES Code: O=C(C1=C(C)C(C2=CC=C(OC(F)(F)F)C=C2)=CC=C1)NC3=CC=C(N4C[C@@H](C)O[C@@H](C)C4)N=C3
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001