CAS 956104-40-8: Apalutamide (ARN-509)

  • CAS 956104-40-8: Apalutamide (ARN-509)

CAS 956104-40-8: Apalutamide (ARN-509)
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  • CAS Number: 956104-40-8
  • Stock: 427g
  • Assay: 99.34%

Apalutamide (ARN-509), CAS 956104-40-8

Apalutamide (ARN-509), CAS 956104-40-8, Stock 427g, Assay 99.34%, White powderEOS Med Chem is big manufacturer of Apalutamide (ARN-509).

Apalutamide (ARN-509)

Apalutamide, also known as ARN-509 and JNJ-56021927 , is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.

Product Details:

Name: Apalutamide (ARN-509)

CAS#: 956104-40-8 (free base)

Chemical Formula: C21H15F4N5O2S

Exact Mass: 477.08826

Molecular Weight: 477.43

Elemental Analysis: C, 52.83; H, 3.17; F, 15.92; N, 14.67; O, 6.70; S, 6.72


Related CAS #: 1505451-73-9 (ethanol)   956104-40-8 (free base)   1505451-74-0 (hydrate)   1505451-77-3 (DMSO)   2376466-25-8 (acetate)    

Synonym: ARN509; ARN 509; ARN-509; JNJ56021927; JNJ-56021927; JNJ 56021927; Apalutamide

IUPAC/Chemical Name: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide


InChi Code: InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

SMILES Code: O=C(NC)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F

Appearance: white to off-white solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO (50 mg/mL)

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001