CAS 955365-80-7 : MK-1775

  • CAS 955365-80-7 : MK-1775

CAS 955365-80-7 : MK-1775
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 955365-80-7
  • Stock: 323g
  • Assay: 99.34%

MK-1775, CAS 955365-80-7

MK-1775, CAS 955365-80-7, Stock 323gAssay 99.34%, Yellow powderEOS is big manufacturer of  MK-1775.


MK-1775, also known as Adavosertib and AZD-1775, is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2), to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.

Product Details:

Name: MK-1775

CAS#: 955365-80-7

Chemical Formula: C27H32N8O2

Exact Mass: 500.26482

Molecular Weight: 500.6

Elemental Analysis: C, 64.78; H, 6.44; N, 22.38; O, 6.39


Synonym: MK-1775; MK1775; MK 1775; AZD1775; AZD-1775; AZD 1775; adavosertib.

IUPAC/Chemical Name: 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one


InChi Code: InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)


Appearance: Yellow solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001