CAS 571170-77-9 : Laropiprant
(World's Largest Pharmaceutical Supplier)
- CAS Number: 571170-77-9
- Stock: 250g
- Assay: 99.30%
CAS 571170-77-9: Laropiprant
CAS 571170-77-9: Laropiprant, Stock 250g, Assay 99.3%, White powder.
Laropiprant, aslo known as MK-0524, was a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold, due to increases in side-effects with no cardiovascular benefit. Laropiprant itself has no cholesterol lowering effect, but it reduces facial flushes induced by niacin. Laropiprant acts as a selective DP1 antagonist, reducing the vasodilation.
Chemical Formula: C21H19ClFNO4S
Exact Mass: 435.0707
Molecular Weight: 435.89
Elemental Analysis: C, 57.87; H, 4.39; Cl, 8.13; F, 4.36; N, 3.21; O, 14.68; S, 7.35
Synonym: MK-0524; MK0524; MK 0524; Laropiprant. Trade name: Cordaptive, Tredaptive.
IUPAC/Chemical Name: ((3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta(b)indol-3-yl)acetic acid
InChi Key: NXFFJDQHYLNEJK-CYBMUJFWSA-N
InChi Code: InChI=1S/C21H19ClFNO4S/c1-29(27,28)18-10-15(23)9-17-16-7-4-13(8-19(25)26)20(16)24(21(17)18)11-12-2-5-14(22)6-3-12/h2-3,5-6,9-10,13H,4,7-8,11H2,1H3,(H,25,26)/t13-/m1/s1
SMILES Code: O=C(O)C[C@H]1CCC2=C1N(CC3=CC=C(Cl)C=C3)C4=C2C=C(F)C=C4S(=O)(C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001