CAS 543906-09-8: Mavoglurant
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- CAS Number: 543906-09-8
- Stock: 268g
- Assay: 99.20%
Mavoglurant, CAS 543906-09-8
Mavoglurant, CAS 543906-09-8, Stock 268g, Assay 99.20%, Off-white or White powder, EOS Med Chem is big manufacturer of Mavoglurant.
Mavoglurant, aslo known as AFQ056, is a potent, selective, non-competitive and orally active mGluR5 antagonist, In vitro, mavoglurant had an IC50 of 30 nM in a functional assay with human mGluR5 and was selective over the other mGluR subtypes, iGluRs and a panel of 238 CNS relevant receptors, transporter or enzymes. In vivo, mavoglurant showed an improved pharmacokinetic profile in rat and efficacy in the stress-induced hyperthermia test in mice as compared to the prototypic mGluR5 antagonist MPEP.
Chemical Formula: C19H23NO3
Exact Mass: 313.1678
Molecular Weight: 313.397
Elemental Analysis: C, 72.82; H, 7.40; N, 4.47; O, 15.32
Synonym: AFQ056; AFQ-056; AFQ 056; Mavoglurant.
IUPAC/Chemical Name: methyl (3aR,4S,7aR)-4-hydroxy-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate
InChi Key: ZFPZEYHRWGMJCV-ZHALLVOQSA-N
InChi Code: InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)8-11-19(22)10-4-7-17-16(19)9-12-20(17)18(21)23-2/h3,5-6,13,16-17,22H,4,7,9-10,12H2,1-2H3/t16-,17-,19-/m1/s1
SMILES Code: O=C(N1CC[C@@]2([H])[C@@](C#CC3=CC=CC(C)=C3)(O)CCC[C@@]12[H])OC
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001