CAS 540737-29-9: Tofacitinib citrate

CAS 540737-29-9: Tofacitinib citrate
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 540737-29-9
  • Stock: 268g
  • Assay: 99.20%

Tofacitinib citrate, CAS 540737-29-9

Tofacitinib citrate, CAS 540737-29-9, Stock 268g, Assay 99.20%, Off-white or White powder, EOS Med Chem is big manufacturer of Tofacitinib citrate.

Tofacitinib citrate

Tofacitinib, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.

Product Details:

Name: Tofacitinib citrate

CAS#: 540737-29-9 (citrate)

Chemical Formula: C22H28N6O8

Exact Mass:

Molecular Weight: 504.5

Elemental Analysis: C, 52.38; H, 5.59; N, 16.66; O, 25.37


Synonym: Tofacitinib citrate; CP690550; CP-690550; CP 690550; CP-690550-10; CP-690,550-10; CP-690550 citrate; Tofacitinib; tasocitinib. Trade name Xeljanz.

IUPAC/Chemical Name: 1-Piperidinepropanenitrile, 4-methyl-3-(methyl-7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)- beta-oxo-, (3R,4R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)


InChi Code: InChI=1S/C16H20N6O.C6H8O7/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t11-,13+;/m1./s1

SMILES Code: N#CCC(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)=O.O=C(CC(C(O)=O)(O)CC(O)=O)O

Appearance: White to off-white solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001